GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs9457247 | 1 | rs422094 | chr6:167397033 | RNASET2 | chr6:167343008-167412795:- | -0.24 | -5.08 | 5.88E-7 | Crohn's disease |
| BLCA | cis | rs2243480 | 1 | rs422164 | chr7:65586605 | CCT6P1 | chr7:65216092-65228661:+ | 0.35 | 4.95 | 1.13E-6 | Diabetic kidney disease |
| BLCA | cis | rs9457247 | 1 | rs422562 | chr6:167406318 | RNASET2 | chr6:167343008-167412795:- | -0.24 | -4.99 | 9.3E-7 | Crohn's disease |
| BLCA | cis | rs9457247 | 1 | rs422694 | chr6:167406074 | RNASET2 | chr6:167343008-167412795:- | -0.25 | -5.16 | 4.07E-7 | Crohn's disease |
| BLCA | cis | rs9457247 | 1 | rs422780 | chr6:167406209 | RNASET2 | chr6:167343008-167412795:- | -0.25 | -5.16 | 4.07E-7 | Crohn's disease |
| BLCA | cis | rs4237643 | 1 | rs4237643 | chr11:43648368 | HSD17B12 | chr11:43702143-43878160:+ | 0.43 | 7.19 | 3.45E-12 | Forced vital capacity |
| BLCA | cis | rs9902453 | 1 | rs4239227 | chr17:28389103 | EFCAB5 | chr17:28256874-28435469:+ | -0.23 | -4 | 7.57E-5 | Coffee consumption (cups per day) |
| BLCA | cis | rs4253772 | 1 | rs4253766 | chr22:46623905 | PKDREJ | chr22:46651561-46659219:- | -0.41 | -4.22 | 3.04E-5 | Cholesterol, total;LDL cholesterol |
| BLCA | cis | rs4253772 | 1 | rs4253772 | chr22:46627603 | PKDREJ | chr22:46651561-46659219:- | -0.43 | -4.11 | 4.92E-5 | Cholesterol, total;LDL cholesterol |
| BLCA | cis | rs4256922 | 1 | rs4256922 | chr10:52568616 | ASAH2B | chr10:52499696-52514567:+ | -0.29 | -3.83 | 0.000152 | Urate levels in lean individuals |
| BLCA | cis | rs4263408 | 1 | rs4263408 | chr4:39785276 | RPL9 | chr4:39455747-39460568:- | -0.42 | -7.07 | 7.46E-12 | Plasma amyloid beta peptide concentrations (ABx-40) |
| BLCA | cis | rs9473555 | 1 | rs4267943 | chr6:49439805 | CENPQ | chr6:49431096-49460820:+ | 0.3 | 6.07 | 3.08E-9 | Folate pathway vitamin levels |
| BLCA | cis | rs9473555 | 1 | rs4267943 | chr6:49439805 | MUT | chr6:49398994-49431031:- | -0.25 | -4.7 | 3.68E-6 | Folate pathway vitamin levels |
| BLCA | cis | rs2243480 | 1 | rs427044 | chr7:65508545 | CCT6P1 | chr7:65216092-65228661:+ | 0.32 | 4.4 | 1.39E-5 | Diabetic kidney disease |
| BLCA | cis | rs4272382 | 1 | rs4272382 | chr8:8433488 | ERI1 | chr8:8860314-8890849:+ | -0.41 | -3.96 | 8.86E-5 | Response to cytidine analogues (gemcitabine) |